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If you have one or more of these symptoms, talk to your doctor or other healthcare professional.”
3. Having bleeding symptoms and someone in your family has a bleeding disorder, such as von Willebrand disease, or a clotting factor deficiency, such as hemophilia
4. Heavy bleeding from dental surgery, other surgery, or childbirth.
5. Frequent nose bleeds that last longer than 10 minutes
6. Bleeding from cuts lasting longer than 5 minutes
7. Easy bruising (weekly, raised and larger than a quarter)
- Heavy menstrual periods
• Bleeding for more than 7 days, from the time it began until it stopped
• Flooding or gushing of blood, limiting daily activities such as work, exercise or social activities
• Passing clots that are bigger than a quarter
•. Changing tampon and/or pad every 2 hours or less on heaviest day
“You may have a bleeding disorder if you have one or more of the following symptoms:
The signs and symptoms of a bleeding disorder or bleeding tendency with normal hemostatic (blood) tests.
Bleeding Not Otherwise Specified or Bleeding of Unknown Cause:
“Platelets play an important role in blood clotting, so when a person has a low number of platelets, too many platelets or their platelets don’t work the way they should, they have a platelet disorder. People with platelet disorders take longer to stop bleeding.
Platelets are tiny, irregularly shaped blood cell pieces (called fragments) that play an important role in the making of blood clots. When an injury occurs and a blood clot is needed, the platelets become sticky and help plug the site of the injury. They attract other proteins needed in the clotting process and they help form a stable clot. There are several ways that platelets may not work properly, which result in platelet disorders. Some platelet disorders are not fully understood and may result in a diagnosis of an "unspecified platelet disorder."
“Von Willebrand disease (VWD) is an inheritable bleeding disorder. Many different proteins are needed to make a person’s blood clot successfully. People with VWD are either missing or low in the clotting protein von Willebrand factor (VWF) – or it doesn’t work as it’s supposed to. For a person to make a successful clot, VWF binds to factor VIII (8), another clotting protein, and platelets in blood vessel walls. This process will help form a platelet plug during the clotting process. People with VWD are not able to form this platelet plug, or it will take longer to form. The condition is named after Finnish physician Erik von Willebrand, who first described it in the 1920s.”
“Factor XI (FXI) deficiency, also called hemophilia C, plasma thromboplastin antecedent deficiency and Rosenthal syndrome, was first recognized in 1953 in patients who experienced severe bleeding after dental extractions. Its incidence is estimated at 1 in 100,000 in the general population. In Israel, FXI deficiency occurs in up to 8% of Ashkenazi Jews because of intermarriage.
FXI plays an important role in the clotting cascade, which leads to a clot. It helps generate more thrombin, a protein that converts fibrinogen to fibrin, which traps platelets and helps hold a clot in place.”
“Hemophilia B, also called factor IX (FIX) deficiency or Christmas disease, is a genetic disorder caused by missing or defective factor IX, a clotting protein. Although it is passed down from parents to children, about 1/3 of cases are caused by a spontaneous mutation, a change in a gene.
According to the US Centers for Disease Control and Prevention, hemophilia occurs in approximately 1 in 5,000 live births. There are between 30,000 – 33,000 people with hemophilia in the US. All races and ethnic groups are affected. Hemophilia B is four times less common than hemophilia A.”
“Hemophilia A, also called factor VIII (8) deficiency or classic hemophilia, is a genetic disorder caused by missing or defective factor VIII (FVIII), a clotting protein. Although it is passed down from parents to children, about 1/3 of cases found have no previous family history.
According to the US Centers for Disease Control and Prevention (CDC), hemophilia occurs in approximately 1 in 5,617 live male births. There are between 30,000 – 33,000 males with hemophilia in the US*. More than half of people diagnosed with hemophilia A have the severe form. Hemophilia A is four times as common as hemophilia B. Hemophilia affects all races and ethnic groups.”
Per the National Bleeding Disorder Foundation, “Bleeding disorders are a group of disorders that share the inability to form a proper blood clot. Symptoms include extended bleeding after injury, surgery, trauma, or menstruation. Sometimes the bleeding is spontaneous, without a known or identifiable cause. Improper clotting can be caused by defects in blood components such as platelets and/or clotting proteins, also called clotting factors. The body produces 13 clotting factors. If any of them are defective or deficient, blood clotting is affected; a mild, moderate or severe bleeding disorder can result.
Some bleeding disorders, such as hemophilia, can be inherited or acquired. Others can occur from such conditions as anemia, cirrhosis of the liver, HIV, leukemia, and vitamin K deficiency. They also can result from certain medications that thin the blood, including aspirin, heparin, and warfarin.”
